Endocrine Abstracts

The common perception is that receptor targeting peptide radiopharmaceuticals of high affinity should be prepared and administered in high specific radioactivity and thus low peptide content in order to assure high contrast uptake in the target tissue. However, both pre-clinical and clinical studies have demonstrated complexity of the translation of the observations in vitro to in vivo pharmacokinetics. The investigation of the phenomenon for clinically used ...

The currently best known example of a commercialized theranostics is the combination of HercepTest and Herceptin wherein the former is used for HER2 expression assessment and selection of patients that might benefit from the treatment with the latter. However, HercepTest requires biopsy which is an invasive procedure, not sufficiently accurate, and very difficult to perform on several lesions and repeatedly in order to monitor the treatment response. While positron emission to...